Suitable for

Postmenopausal women aged 50 years and above who have not had a period for at least 1 year.

How to use

Please read the enclosed leaflet carefully before use.

Patient Information Leaflets are updated periodically by the manufacturer.

For vaginal use

Ovesse is used to treat vaginal symptoms due to oestrogen deficiency in postmenopausal women aged 50 years and above, who have not had a period for at least 1 year. Ovesse is a form of vaginal hormone replacement therapy (HRT).

How much to use

1 applicator filled to the red line (0.5g of cream)

How often to use

Initial dose: 1 application daily for 2 weeks

Maintenance dose: 1 application twice a week

(leave 3 or 4 days between each dose).

Do not use more than the recommended dose.

Restarting treatment after a break: Read the package leaflet

Hazards and Cautions

DO NOT use Ovesse if you:

• • Are allergic to estriol or any of the other ingredients

• • Have or ever had womb or ovarian cancer

• • Have or recently had vaginal or genital bleeding, since your periods stopped due to the menopause

• • Have recent of suspected endometrial hyperplasia (or e.g. you have been referred for an ultrasound or your womb and are awaiting results)

• • Have previously been treated with oestrogen only systemic HRT (without Progestogen) and you have not had your womb removed

• • Have any thickening, lump or scarring on your vulva

• • Have severe vaginal itching, or itchy patches or rash on your vulva

• • Have a current vaginal infection prior to starting treatment

• • Have or ever had breast cancer, or have a lump / change in appearance in your breast, or nipple discharge

• • Have or ever had a blood clot in a vein

• • Have or ever had a heart attack, stroke or angina

• • Have blood clotting disorder

• • Have liver disease and your liver function tests have not returned to normal

• Have a rare condition called ‘porphyria’

Certain conditions may be made worse during oestrogen treatment, see section 2 of the package leaflet for more information.

You may need to speak to your doctor before using Ovesse. Ask your pharmacist for advice if you:

• • Are receiving a type of HRT (including tablets or patches) that circulates in the blood

• • Have a history of endometriosis

• • Have a history of excessive thickening of the womb lining

• Are switching from another vaginal oestrogen

Stop using Ovesse and see a doctor immediately if you notice any of the following during treatment:

• • Any of the conditions mentioned in the ‘DO NOT use Ovesse’ section

• • Any new vaginal bleeding, spotting or itching

• If you have endometriosis and your symptoms come back

Seek prompt advice from your doctor if you:

• • Have yellowing of your skin or the whites of your eyes (jaundice)

• • Have a large rise in your blood pressure (symptoms may be headache, tiredness, dizziness)

• • Get migraine-like headaches which happen for the first time

• Become pregnant

You should inform your doctor at your next appointment that you are using Ovesse.

Keep all medicines out of the sight and reach of children

Storage

Do not store above 25°C. Do not freeze.

Precautions:

This is a medicine:

• • Consult your doctor or pharmacist if you have an underlying medical condition, are taking any other medication or complementary therapy, or if symptoms persist

• Seek advice before using if you are pregnant, planning to become pregnant, breastfeeding or suffer from allergies

Active ingredients

Estriol

Ingredients

Active ingredients: Estriol 1mg in 1g

Also contains: Octyldodecanol; cetyl palmitate; glycerin; cetyl alcohol*; stearyl alcohol*; Polysorbate 60; sorbitan stearate; chlorhexidine hydrochloride; lactoc acid; sodium hydroxide to pH 4, purified water.
*can cause local reactions.